Proteus syndrome (PS) is a rare condition in which bones, skin and other tissues grow out of proportion -- and often asymmetrically -- to the rest of the body. The condition may affect the left and right sides of the body differently. In addition to growth issues, the syndrome may cause large blisters, lung disease, enlargement of one side of the brain, blood clots and vascular malformations.
Vascular malformations associated with Proteus syndrome
Many individuals with Proteus syndrome have skin (cutaneous) capillary malformations, patterns of prominent veins or enlarged veins called varicosities. Large and complex vascular malformations also are sometimes seen in patients with Proteus syndrome.