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The University of Chicago Medicine - Comer Children's Hospital

Types of Vascular Anomalies: Blue Rubber Bleb Nevus Syndrome

Blue rubber bleb nevus syndrome (BRBNS) is a rare condition that occurs when blood vessels develop abnormally in different regions of the body, affecting the skin, soft tissue, and intestinal tract.

Vascular malformations associated with blue rubber bleb nevus syndrome 
Individuals with blue rubber bleb nevus syndrome have visible venous malformations on the skin. These lesions appear blue and feel hard or rubbery to the touch; they may also extend deeper into soft tissue and internal organs. In particular, patients with BRBNS develop lesions in the gastrointestinal tract -- often in the small or large intestine.

Diagnosis and Treatment

The diagnosis and treatment of blue rubber bleb nevus syndrome often requires several types of pediatric experts. The Vascular Anomalies Team at the University of Chicago Medicine Comer Children's Hospital evaluates, treats and monitors the vascular malformations associated with the syndrome and works closely with other specialists involved in the patient's care.

Treatment of vascular anomalies associated with blue rubber bleb nevus syndrome is based on the location of an individual's lesions. It may include:

  • Surgical removal (excision) of the malformation
  • Interventional treatments to limit blood supply to the lesions

About Our Program

The Vascular Anomalies Program at Comer Children's offers an integrated and comprehensive approach to the diagnosis, care and management of hemangiomas and vascular malformations. Our multidisciplinary team of pediatrics experts works together to educate families and to evaluate and treat children with all types of these vascular lesions. » Read more about our program and our team.