Connective tissue is a term that refers to the network of proteins that holds together our muscles, bones, organs, and skin. This includes tendons, ligaments, cartilage, bone and other body tissues. Connective tissue diseases are inherited conditions that affect the proteins of these tissues (particularly the proteins fibrillin and elastin), which results in the connections to the organs they support becoming looser. When there is a concern of the connective tissue within the wall of blood vessels, a pediatric cardiologist helps in the diagnosis and treatment of these patients. Marfan syndrome and Ehlers-Danlos syndrome are two of the most common connective tissue disorders; both can impact a patient's heart and vascular system.