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The University of Chicago Medicine - Comer Children's Hospital

Conditions Treated with Stem Cell Transplant

Stem cell transplant is being used to treat many types of conditions. In most instances, it is used when conventional treatments have been unsuccessful. For some serious diseases such as certain forms of leukemia, bone marrow failure syndrome, some hemoglobinopathies, and Immunodeficiency states, stem cell transplant is emerging as a first-line therapy.

At the University of Chicago Medicine Comer Children's Hospital, our pediatric stem cell transplant team has the experience to care for even the most complex cases. We continually strive to improve the effectiveness of stem cell transplantation and to minimize the side effects associated with this treatment.

We offer cutting-edge treatment strategies using autologous, allogeneic, synergenic, or cord blood grafts as appropriate to treat many conditions, including:

  • Hematologic malignancies particularly:
    • Acute lymphoblastic leukemia (ALL)
    • Acute myelogenous leukemia (AML)
    • Chronic myelogenous leukemia (CML)
    • Juvenile myelomonocytic leukemias (JMML/CMML)
    • Myelodysplastic syndromes (MDS)
    • Secondary leukemias
    • Relapsed/refractory leukemia that has failed other therapies
  • Hodgkin and Non-Hodgkin lymphoma
  • Neuroblastoma
  • Sarcomas
  • Other solid tumors of childhood
  • Hemophagocytic lymphohistiocytosis (HLH)
  • Hemoglobinopathies including sickle cell anemia and β-thalassemia
  • Aplastic anemia
  • Fanconi anemia
  • Rare blood diseases including chronic granulomatous disease, Chediak-Higashi and Schwachman-Diamond syndromes, and dyskeratosis congenita disease
  • Paroxysmal nocturnal hemoglobinuria
  • Bone marrow failure syndromes
  • Metabolic/lysosomal storage diseases
  • Immunodeficiencies including severe combined immunodeficiency (SCID) and Wiskott-Aldrich Syndrome
  • Autoimmune conditions including systemic lupus erythematosus (SLE), rheumatoid arthritis and scleroderma