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Samuel L. Volchenboum, MD, PhD, MS

Associate Professor of Pediatrics

Director, Informatics Program

Samuel L. Volchenboum, MD, PhD, MS, is an expert in pediatric cancers and blood disorders. He has a special interest in treating children with neuroblastoma, a tumor of the sympathetic nervous system.

In addition to caring for patients, Dr. Volchenboum is studying neuroblastoma in the laboratory, using sophisticated tools to measure the amounts of proteins found in these tumors. He is also pursuing several research projects in biomedical informatics, a field that harnesses tools from the world of computer science to solve complex problems in biology. Dr. Volchenboum has applied informatics techniques to study the genetics of both pediatric and adult cancers, and serves as director of informatics for the Section of Pediatric Hematology/Oncology.

In 2009, Dr. Volchenboum was named a St. Baldrick's Foundation Scholar. St. Baldrick's awarded him $330,000 in support of his research into using real-time proteomics to distinguish types of neuroblastoma. While current tests can take weeks, it's hoped that a real-time diagnosis is possible, which could lead to faster, more tailored treatment for each child. St. Baldrick's is an organization that raises funds for pediatric cancer research and encourages volunteers and award recipients to shave their heads in solidarity with children who have lost their hair to chemotherapy. Dr. Volchenboum accepted the head-shaving challenge in the fall of 2009.

Practice Locations

Duchossois Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

The University of Chicago Medicine Comer Children's Hospital
5721 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Board Certifications

Pediatric Hematology/Oncology

Medical School

Mayo Medical School


Cincinnati Children's Hospital Medical Center


Children's Hospital, Boston (Harvard Medical School)
Dana-Farber Cancer Institute, Boston

Master's Degree

Massachusetts Institute of Technology, Boston
(Biomedical Informatics)


American Medical Informatics Association
American Society of Clinical Oncology
American Society of Pediatric Hematology/Oncology
Children's Oncology Group
The International Society for Computational Biology

Language Spoken




Office Phone

(773) 702-4303

Office Fax

(773) 834-1329

Office Postal Address

Samuel L. Volchenboum, MD, PhD, MS
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 4060
Chicago, IL 60637

Physician Photo

Clinical Interests

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Learn More About Dr. Volchenboum

Learn how Dr. Volchenboum is using applied informatics techniques to better define cancer diagnoses, which in turn will allow physicians to create more tailored treatment plans.

Read Dr. Volchenboum's account of his experience caring for one young girl with high-risk neuroblastoma, and the role experimental treatments played in saving the girl's life.

Read about Dr. Volchenboum's neuroblastoma research and see photos from the St. Baldrick's event when he had his head shaved for science.

Selected Publications

View a partial list of Dr. Volchenboum's publications through the National Library of Medicine's PubMed online database.

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The University of Chicago Medicine Comer Children's Hospital  |   5721 S. Maryland Avenue   |   Chicago, IL 60637